Log2 transformed data is normalized using the function "justvsn" from the VSN package.
Source:R/normMethods.R
performVSNNormalization.RdThe VSN (Variance Stabilizing Normalization) attempts to transform the data in such a way that the variance remains nearly constant over the intensity spectrum
Examples
data(example_data_only_values_small)
normMatrix <- performVSNNormalization(example_data_only_values)